MatriDerm®

Flexible solutions for complex wound reconstruction

MatriDerm® is a unique collagen-elastin-template, which serves as a dermal replacement scaffold and can be applied both in a One- and Multi-Step Procedure.

      • Open porous matrix
      • No chemical cross-linking
      • Native collagen fibers
      • Contains Elastin

MatriDerm® Scientific Rationale

MatriDerm® Clinical Performance

MatriDerm® Indications

MatriDerm® Scientific Rationale

MatriDerm® is able to preserve closeness to human dermis, accelerate cell invasion, cell elongation and proliferation and limit myofibroblast formation and contraction. This scientific performance is as a result of our Advanced CryoSafe® Method which gently preserves the native structure with no chemical crosslinking.

1. Dill V and Moergelin M, Int Wound J 2020;17(3):618-630
2. Böhm S et al.; Materials 2017; 10(9), 1086

 

ACCELERATES

In an animal AV-Loop model number of new formed blood vessels were analyzed in wounds treated with either with MatriDerm® Dermal Matrix or competitor product. MatriDerm Dermal Matrix accelerates revascularization.

Schmidt VJ et al., Ann Plast Surg. 2017;79(1):92-100

 

LIMITS

In vitro analysis of the formation of myofribroblast phenotype by α-SMA staining. MatriDerm® Dermal Matrix limits myofibroblast formation compared to competitor products. Myofibroblast formation is associated with wound contraction. Limited wound contraction is observed with MatriDerm.3,4,5

1. Dill V and Moergelin M, Int Wound J 2020;17(3):618-630.

 

 

 

2. Kattan WM et al., J Coll Physicians Surg Pak 2017;27:38-43.

3. De Vries H et al., Wound Repair Regen. 1994;2(1):37-47.

4. De Vries HJ et al., Br J Dermatol. 1995;132(5):690-7.

5. Hur GY, Seo DK, Lee JW., Burns. 2014;40(8):1497-503.

*By measurement of α-SMA positive fibroblasts

MatriDerm® Clinical Performance

Ensures Active Healing

In diabetic foot ulcers the combination of MatriDerm with STSG lead to a shorter healing period compared to STSG alone.

Modified according to Jeon H. et al., ArchPlast Surg2013, 40(4):403-8

* p=0.010

1. Compared to STSG alone

Cost Effective

In an RCT the total surgical treatment costs of Full-thickness wounds treated with STSG alone or with MatriDerm Dermal Matrix and STSG were analyzed. The costs do not differ significantly.

Modified according to Hop M. et al., Burns 2013, 40(3):388-96

 

 

Improves Quality of Wound Healing

Long term follow-up study of an intra-individual comparison of patients treated with STSG alone and with MatriDerm Dermal Matrix and STSG to analyze different skin parameter after 12 years of treatment. It demonstrate a long lasting effect on scar quality even after 12 years by the use of MatriDerm Dermal Matrix compared to STSG alone.

Modified according to Bloemen MC et al., Plast Reconstr Surg, 2010, 125(5):1450-9

 

 

1. Compared to STSG alone

* p<0.05

MatriDerm® Indications

 

  • Burns / Reconstructive
  • Burns / Acute
  • Trauma and Acute Wounds
  • Chronic Wounds
  • Cancer Excision
  • Adhesion Barrier
  • Donor Sites
  • Mucosal Defects